Loading...
HomeMy WebLinkAboutzka-virus-pediatric-hsieh-01242018-archiveZika Virus for Pediatric Providers Charlotte J. Hsieh, MD FAAP UCSF Benioff Children’s Hospital Oakland Bay Area Infectious Disease Conference for Perinatal and Pediatric Providers January 24, 2018 Disclosures •None Disclaimer Recommendations subject to change based on CDC and CDPH. See their websites for the most up to date information and recommendations: •https://www.cdc.gov/zika/ •https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/Zika.aspx Objectives 1.Identify risks for Zika transmission and infection. 2.Recognize clinical features of Zika infection – congenital and pediatric 3.Use Zika testing algorithms to identify children at risk for congenital Zika infection and understand long term care of affected children. THE RISE OF ZIKA VIRUS Zika Virus –Origins •1947 –New virus identified in rhesus monkey placed in Zika forest of Uganda; named Zika virus (ZIKV). •1948 –Zika virus recovered from Aedes africanus mosquito caught in Zika forest. •1962-1963 –First human case of Zika virus infection –Uganda. EPA/STR WHO –The History of Zika Virus timeline Petersen et al, “Zika Virus”, NEJM, April 21, 2016 Gubler, et al, “History and Emergence of Zika Virus”, JID 2017:216 Frontline -http://apps.frontline.org/zika/ Zika Virus –History •1964 –Researcher in Uganda infected with Zika –Has “mild” febrile illness. •1960s-1980s –Human cases confirmed through blood tests. –No deaths or hospitalizations. –Disease moves from Uganda to western Africa and Asia. •1969-1983 –Zika virus detected in mosquitoes found in equatorial Asia –India, Indonesia, Malaysia, Pakistan •Only 13 naturally acquired cases reported in 57 years. WHO –The History of Zika Virus timeline Petersen et al, “Zika Virus”, NEJM, April 21, 2016 Frontline -http://apps.frontline.org/zika/ Zika Virus –First Outbreak •Apr-May 2007 –Yap Island, Federated States of Micronesia •Outbreak of rash, conjunctivitis, arthralgia •Zika virus RNA or specific ZIKV neutralizing antibody detected •49 confirmed, 59 probable cases of Zika virus disease •~73% Yap residents infected •~18% symptomatic •No deaths or hospitalizations. •First cases outside Africa and Asia. Duffy et al, NEJM, June 11 2009 Wikipedia http://www.dankainmicronesia.com/islands.html Zika Virus –Early Outbreaks •More Outbreaks –French Polynesia (2013, 2014) –New Caledonia (2014) –Easter Island (2014) –Cook Islands (2014) •Dec 2013, Feb 2014 – Evidence of perinatal transmission of ZIKV in French Polynesia –Two mothers and their newborns infected with ZIKV. –Suspected transplacental transmission or during delivery. •March 2014 –ZIKV detected in blood of asymptomatic blood donors (French Polynesia) WHO –The History of Zika Virus timeline Besnard et al, EuroSurveill, April 2014 Zika Virus –The Americas •March 2015 –Outbreak of exanthematous illness identified in Bahia, Brazil. –Campos et al –identified ZIKV in sera of patients –Outbreak Feb to June 2015 –By Dec 2015 –estimated 1.3 million suspected cases •By March 2016, spread to 33 countries and territories in the Americas Campos et al, Emerg Inf Dis, Oct 2015 Petersen et al, “Zika Virus”, NEJM, April 21, 2016 Hills et al, “Epidemiology of Zika Virus Infection”, JID 2017:216 WHO Suspected and Confirmed Zika virus disease cases in the Americas May 2015 Dec 2016 Microcephaly in Infants in Brazil •By Sept 2015 –noted increase in infants born with microcephaly. •By Feb 2016 > 4,300 cases of microcephaly. •Overlap with Zika outbreak areas. •Also noted in French Polynesia •WHO declares Public Health Emergency of International Concern March 10, 2016 –WHO Petersen et al, “Zika Virus”, NEJM, April 21, 2016 Case report of severe fetal brain injury associated with Zika virus infection in a woman pregnant in Brazil in Feb 2015. Woman sick during end of 1st trimester. Abnormal fetal ultrasound at 29 weeks gestation. ZIKV detected by RT-PCR in fetal brain tissue on autopsy. March 10, 2016 “Sufficient evidence has accumulated to infer a causal relationship between prenatal Zika virus infection and microcephaly and other severe brain abnormalities.” Emerging Infectious Diseases, March 2017 Zika virus exhibits neurotropism. Found evidence of Zika virus replication and persistence in fetal brain and placenta. May 19, 2016 “Never before in history has there been a situation where a bite from a mosquito could result in a devastating malformation.” Dr. Tom Frieden CDC Director, April 13, 2016 ZIKA VIRUS AND TRANSMISSION Zika Virus •Single stranded RNA virus, Flavivirus –Arbovirus = Arthropod-borne virus •Closely related to dengue, yellow fever, Japanese encephalitis, and West Nile viruses •Mosquito-borne transmission –Aedes sp. –Aedes aegypti and Aedes albopictus ZIKV, C. Goldsmith/CDC Aedes aegypti Aedes albopictus CDC Daytime biting mosquitoes. Feed indoors and outdoors. Current Zika transmission worldwide European Centre for Disease Prevention and ControlDecember 19, 2017 https://ecdc.europa.eu/en/publications-data/current-zika-transmission-worldwide https://www.cdc.gov /zika/pdfs/Zika- mosquito-maps.pdf As of Sept 20, 2017 CA Dept Public Health No local mosquito- borne transmission of Zika virus in California to date. https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/AedesDistributionMap.pdf https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/LocalZikaRiskMap.pdf https://www.cdc.gov/zika/pdfs/Zika-Transmission-Infographic.pdf Zika Transmission -Mosquitoes Slavov et al, “Overview of Zika virus infection in regards to Brazilian epidemic,” Brazilian Journal of Medical and Biological Research, 2016. Zika Transmission –Maternal-Child •In utero / transplacental –Confirmed –Mothers with evidence of infection. –Fetus can be affected. •Peripartum –Two cases in French Polynesia 2013-2014 –Mothers sick around time of delivery, infants infected (one asymptomatic, one transient hepatitis) •Breastfeeding ?? –Zika virus detected in breast milk –No transmission documented yet Besnard et al, Emerg Infect Dis, Aug 2017. WHO, CDC, Colt et al, PLOS Negl Trop Dis April 10, 2017. Zika Transmission -Horizontal •Sexual transmission –Male to female, female to male, male to male –Vaginal, anal, oral, sex toys •Time to loss of detectable virus: –Semen: virus detected in one case up to 188 days after illness onset! •Urine, saliva –no cases of transmission •Abstinence / condoms after illness onset –Women: 8 weeks –Men: 6 months Paz-Bailey et al, NEJM, Feb 14, 2017 Nicastri et al, Euro Surveill, 2016 Aug 11 Zika Transmission –Other •Blood transfusion ?? –No confirmed cases in US –Rare reports of blood/ platelet transmission in Brazil •under investigation –French Polynesia outbreak: •2.8% of asymptomatic blood donors tested positive for Zika virus –Zika virus screening of blood supply in US No confirmed reported Zika virus transmission in healthcare settings in U.S. •One lab-acquired case as of June 15, 2016 (Penn – needle stick injury). CDC Gregory et al, “Modes of Transmission of Zika Virus,” JID 2017:216 States: 5,102 symptomatic Zika virus cases reported 4,830 cases from returning travelers from affected areas 224 cases from local mosquito-borne transmission (in Florida and Texas) 48 cases from other routes (46 sexual, 1 lab, 1 person-to-person) Zika in the US 2016 Territories: 36,079 cases 142 travelers 35,937 mosquito 0 other routes https://www.cdc.gov/zika/reporting/2016-case-counts.html Zika in the US 2017 States: 407 symptomatic Zika virus cases reported 398 cases from returning travelers from affected areas 4 case from local mosquito-borne transmission 5 cases from sexual transmission Territories: 631 cases 1 travelers 630 mosquito 0 other routes https://www.cdc.gov/zika/reporting/2017-case-counts.html CDPH Monthly Update on Number of Zika Virus Infections in CA as of January 5, 2018 Snapshot of Bay Area County residents with Zika Virus Infection during 2015-2017 2015- 2016 2017 Total Alameda 32 7 39 City of Berkeley 3 3 6 Contra Costa 26 4 30 San Francisco 29 11 40 TOTAL 90 25 115 Travel-associated infections with Zika virus in CA residents during 2015-2017 Total Infections 634 Cumulative number of infections due to sexual transmission 9 Cumulative number of infections in pregnant women 168 Cumulative number of completed pregnancies 142 Live-born infants with birth defects 10 https://www.cdph.ca.gov/Progra ms/CID/DCDC/CDPH%20Docume nt%20Library/TravelAssociatedC asesofZikaVirusinCA.pdf ZIKA VIRUS DISEASE, DIAGNOSIS AND MANAGEMENT Incubation and Viremia •Incubation period: ~3 -14 days •Viremia: a few days to 1 week –Longer in some pregnant women •Virus remains in semen and urine longer than in blood. •Most infections are asymptomatic (~80%). Clinical Disease •Usually mild illness: –Acute onset fever –Maculopapular rash –Joint pain / arthralgia –Conjunctivitis –(Headache) –(Muscle pain / myalgia) •Symptoms last several days to a week. •Severe disease uncommon. •Fatalities rare. •Once infected, likely protected. •Guillain-Barre syndrome reported CDC Reported clinical symptoms among confirmed Zika virus disease cases Yap Island, 2007 Duffy M. N Engl J Med 2009 Clinical features: Zika virus compared to dengue and chikungunya Rabe, Ingrid MBChB, MMed “Zika Virus-What Clinicians Need to Know?” (presentation, Clinician Outreach and Communication Activity (COCA) Call, Atlanta, GA, January 26 2016) Zika virus and Pregnancy •Pregnant women can be infected by –Mosquito bite –Unprotected sex with infected partner (with or without symptoms). •No evidence of increased susceptibility or more severe disease. –Clinical disease is similar in pregnant and nonpregnant persons. •Previous infection may confer immunity for future pregnancies. •Avoid travel to Zika virus risk areas. CDC Clinical Management •No antiviral treatment available. •Supportive care –Rest –Drink fluids to prevent dehydration –Antipyretics –acetaminophen –Avoid aspirin and NSAIDs until dengue ruled out (due to risk of bleeding) CDC Diagnosis •Based on clinical features, places and dates of travel, and activities. •Laboratory diagnosis –detecting viral nucleic acid or specific IgM and neutralizing antibodies. •Reporting: Nationally notifiable condition. –Report suspected cases to state or local health departments. RT-PCR •Serum/blood, CSF –w/in 14 days of illness onset (symptomatic case) or last potential exposure (asymptomatic pregnant woman) •Urine –w/in 21 days of illness onset (SC), w/in 14 days of last exposure (APW) •Amniotic fluid (amniocentesis) IgM and PRNT •Asymptomatic pregnant women –2 to 12 weeks after last possible exposure •Symptomatic cases: >3 days after illness onset, up to 12 weeks after Contact local public health dept for testing. Suspect cases: VRDL tests for Zika, Chikungunya, Dengue https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/ZikaLaboratoryTestingGuidance_VRDL.pdf 9/20/2017 No Asymptomatic: •Men •Children •Non-pregnant women ONGOING exposure Aug 25, 2017 https://www.cdc.gov/zika/hc-providers/testing-guidance.html https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/UpdatedZikaGuidancef orHCPsCaringforPregnantWomen.pdf August guidance differed from CDC with respect to pregnant women without ongoing exposure. As of January 10, 2018, CDPH and CDC recs are now aligned. https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/ZikaAlgorithmPoster.pdf CDPH: Who to test? (adults) Who to Test?When and with what tests? Non-pregnant symptomatic patient with possible Zika exposure •recent travel to area with risk of Zika virus or •recent unprotected sexual contact with recent traveler to area with risk of Zika virus (male w/in 6 months, female w/in 8 weeks) •NAT testing of serum <2 wks and urine <3 wks since symptom onset •IgM antibody testing <12k wks since symptom onset •If non-neg IgM and ZIKV NAT neg, confirm with PRNT Symptomatic pregnant woman with possible Zika exposure •Concurrent ZIKV NAT in serum and urine and IgM antibody testing if ≤12 wks since symptom onset •If non-neg IgM and ZIKV NAT neg, confirm with PRNT CDPH –Jan 2018 https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/UpdatedZika GuidanceforHCPsCaringforPregnantWomen.pdf CDPH: Who to test? (adults) Who to Test?When and with what tests? Asymptomatic pregnant woman with an episode of Zika exposure (without ongoing exposure) •Do not routinely test, but assess carefully for risk factors that increase likelihood of Zika infection. Test based on risk tolerance. •If choosing to test, follow instructions for Symptomatic Pregnant Woman •Risk Factors •Local Zika transmission at time of exposure •Unprotected sexual exposure to partner with travel to Zika-risk area •Longer duration of travel (>4wk) or multiple sexual exposures •Higher risk activities (outdoor) •Known mosquito bites •Lack of protective clothing and insect repellent on regular basis •Compromised integrity of housing •Other household members with Zika infection •High risk patient occupation (lab worker) •Recipient of recent transfusions or transplants CDPH –Jan 2018 CDPH: Who to test? (adults) Who to Test?When and with what tests? Asymptomatic Pregnant Woman with ongoing (daily or weekly) possible Zika exposure •NAT testing of serum and urine 3 times during pregnancy. Consider qTrimester testing. •IgM testing may be considered with NAT testing, but may have difficult interpretation depending on exposure history. Pregnant woman with recent possible Zika exposure and fetal prenatal ultrasound with findings consistent with congenital Zika virus syndrome. •Testing to include both NAT and IgM tests. •If amniocentesis performed, send NAT testing of amniotic fluid. Case by case: 1) Symptomatic mothers with probable Zika virus infection and 2)mother with infant/fetus with possible Zika virus-associated birth defects but no definitive diagnosis of Zika virus infection during pregnancy. •Pathology testing of placental tissues •Placental Zika virus testing –on a case by case basis in consultation with Public Health. CDPH –Jan 2018 Case •25 yo woman had positive pregnancy test in Sept 2015 in El Salvador. •Developed fever and rash in Oct 2015, lasting about 2 weeks, recovered completely. •First trimester ultrasound revealed twin pregnancy but single fetal demise. •Moved to U.S. in Jan 2016. Fetal ultrasound abnormal. •Fetal MRI Feb 2016: Case •TORCH evaluation negative •Zika IgM equivocal •Infant born full term via NSVD, Apgars 8 and 9 •HC 28.5 cm (<<5%) •Other abnormalities on exam •Data for pregnant women in the US Zika Pregnancy Registry (USZPR). •Women with lab evidence of possible Zika infection: –About 6% of fetuses or infants had birth defects potentially related to Zika virus. –Birth defects similar for symptomatic and asymptomatic women: ~6% –Birth defects in ~11% of women with exposure or symptoms in 1st trimester. Dec 13, 2016 Congenital Zika Syndrome Distinct pattern of congenital anomalies and problems unique to fetuses and infants infected with Zika virus before birth -five main features: 1.Severe microcephaly in which skull has partially collapsed 2.Decreased brain tissue with a specific pattern of brain damage, including subcortical calcifications 3.Damage to the back of the eye, including macular scarring and focal pigmentary retinal mottling 4.Congenital contractures, such as clubfoot or arthrogryposis 5.Hypertonia restricting body movement soon after birth CDC •Cranial Morphology: Fetal brain disruption sequence (FBDS) –Severe microcephaly –Overlapping cranial sutures –Prominent occipital bone –Redundant scalp skin (excess nuchal skin) –Severe neurological impairment –Can have craniofacial disproportion with depression of frontal bones and parietal bones. –Suspected due to loss of brain volume and decrease in intracranial pressure. Moore et al, JAMA Pediatrics, March 2017 Congenital Zika Syndrome •Brain Anomalies –Diffuse, primarily subcortical calcifications –Increased fluid spaces (ventricular, extra-axial) –Marked cortical thinning with abnormal gyral patterns (polymicrogyria) –Hypoplasia or absence of corpus callosum –Decreased myelination –Cerebellar or cerebellar vermis hypoplasia Moore et al, JAMA Pediatrics, March 2017 •Case: Postnatal ultrasound –Marked hydrocephalus and thinning of cortical mantle –Redundant skin in posterior neck Congenital Zika Syndrome •Ocular Anomalies –Structural eye anomalies (microphthalmia, coloboma) –Cataracts –Intraocular calcifications –Posterior ocular findings, macular scarring –Chorioretinal atrophy, focal pigmentary mottling of retina, optic nerve atrophy/anomalies •Congenital contractures –Arthrogryposis multiplex congenita, arthrogryposis –Clubfoot –Bilateral congenital hip dislocation Moore et al, JAMA Pediatrics, March 2017 MMWR October 20, 2017 Congenital Zika Syndrome •Neurological Sequelae and Prognosis –Likely to be severely impaired. –Motor, cognitive disabilities, seizures, swallowing difficulties -> failure to thrive, vision loss, sensorineural hearing loss –Irritability, excessive crying, hypertonia and spasticity, dysphagia, occasionally hypotonia. –Abnormal EEG, tremors and posturing (extrapyramidal dysfunction), epilepsy, abnormal tone or movements Moore et al, JAMA Pediatrics, March 2017 MMWR October 20, 2017 https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/ZikaAlgorithmPoster.pdf CDPH: Who to test? (newborns) Who to Test?Collect tests within first 2 days of life: 1)Infants born to mothers with laboratory evidence of possible Zika virus infection during pregnancy 2)Infants with clinical findings suggestive of congenital Zika syndrome and possible maternal Zika virus exposure during pregnancy, regardless of maternal testing results. •NAT of serum and urine and IgM concurrently. •If non-neg IgM and negative Zika virus NAT, confirm with PRNT. •If CSF collected for other purposes, send for NAT and IgM antibody testing. •For infants with clinical findings consistent with congenital Zika syndrome with unknown etiology, consider testing CSF for Zika virus NAT and IgM antibodies. CDPH –Jan 2018 https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/UpdatedZika GuidanceforHCPsCaringforPregnantWomen.pdf Infant Zika Testing •Collect samples within 2 days of life (ideally). •Consider sending infant specimens for concurrent testing if maternal testing is to be done. •Consider Placental storage/fixation if needed for testing https://www.cdc.gov/zika/pdfs/collection-submission-specimens-zika-testing-at-birth.pdf •Infant serum •Placental and fetal membranes •Umbilical cord •Infant urine Case –Infant testing results •VRDL: –Zika IgM >1:10 detected, PCR not detected –Dengue IgM not detected, PCR not detected •CDC: –Zika PRNT >1280 (positive) –Dengue PRNT >1280 (positive) MANAGEMENT OF NEWBORNS EXPOSED TO ZIKA VIRUS •Most up to date recommendations by CDC so far. •CDPH refers to CDC recommendations for management and evaluation. MMWR October 20, 2017 More recent findings •Eye findings in infants without microcephaly or other brain anomalies. •Postnatal onset microcephaly in infants born with normal head circumferences •Postnatal onset hydrocephalus in infants born with microcephaly •Abnormalities on sleep EEG in some infants with microcephaly who did not have recognized seizures. •Diaphragmatic paralysis in infants born with microcephaly and arthrogryposis. MMWR October 20, 2017 Updated management for possible maternal Zika virus exposure scenarios Who needs further testing/evaluation?Who does not? Infants with clinical findings consistent with congenital Zika syndrome regardless of maternal testing results Infants without clinical findings consistent with congenital Zika syndrome who were born to mothers without laboratory evidence of possible Zika virus •Routine pediatric care Infants without clinical findings consistent with congenital Zika syndrome who were born to mothers with laboratory evidence of possible Zika infection MMWR October 20, 2017 Standard Evaluation •All infants born to mothers with possible Zika virus exposure during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit: –Comprehensive physical exam (with growth parameters) –Age-appropriate vision screening and developmental monitoring and screening using validated tools –Newborn hearing screen at birth (preferably ABR) MMWR October 20, 2017 MMWR October 20, 2017 Infants with abnormalities consistent WITH congenital Zika syndrome born to mothers with possible Zika exposure in pregnancy https://www.cdc.gov/zika/pdfs/pediatric-evaluation-follow-up-tool.pdf Infants with abnormalities consistent WITH congenital Zika syndrome born to mothers with possible Zika exposure in pregnancy ** ABR needed if initial was otoacoustic emissions methodology. Infants with abnormalities consistent WITH congenital Zika syndrome born to mothers with possible Zika exposure in pregnancy Management •Refer to developmental specialist and early intervention services. •Provide family support services. •Consider additional consultations with: –Infectious diseases specialist –Clinical geneticist –Neurologist –Other clinical specialists based on clinical findings of infant MMWR October 20, 2017 Infants with abnormalities consistent WITH congenital Zika syndrome born to mothers with possible Zika exposure in pregnancy Consult with Specialists •Infectious Diseases –r/o congenital infections, help with Zika testing/counseling •Neurologist –by 1 mo, comprehensive evaluation, consider advanced neuroimaging, EEG •Ophthalmologist –by 1 mo, comprehensive eye exam •Geneticist –confirm phenotype, evaluate for other causes of microcephaly or congenital anomalies •Early intervention and developmental specialists •Family and supportive services Other specialists as indicated: •Endocrine –hypothalamic or pituitary dysfunction, thyroid testing •Orthopedist, physiatrist, PT –hypertonia, clubfoot, arthrogryposis •Pulmonologist, ENT –aspiration concerns MMWR October 20, 2017 Local Services •Early Start –CA –http://www.dds.ca.gov/earlystart/index.cfm •Regional Center –CA –http://www.dds.ca.gov/RC/index.cfm •California Children’s Services –http://www.dhcs.ca.gov/services/ccs/Pages/default.aspx •Family Resource Centers Network of California –http://www.frcnca.org/ •Maternal, Child and Adolescent Health (CDPH) –https://www.cdph.ca.gov/Programs/CFH/DMCAH/Pages/default .aspx •Regional Perinatal Programs of CA (CDPH) –https://www.cdph.ca.gov/Programs/CFH/DMCAH/RPPC/Pages/ Default.aspx Infants with abnormalities consistent WITH congenital Zika syndrome born to mothers with possible Zika exposure in pregnancy Further management •Respiratory distress/failure or fails to wean from ventilator - > evaluate for diaphragmatic paralysis •Monitor feeding for swallowing dysfunction, dysphagia •Signs of increased ICP -> neuroimaging for postnatal hydrocephalus •Establish medical home for coordination of care and to ensure abnormal findings are addressed –Routine pediatric care with standard evaluation, immunizations, etc. •f/u eye exams as needed as per ophthalmologist •No need for 4-6 mo ABR –no delayed-onset hearing loss noted thus far MMWR October 20, 2017 Infants WITHOUT findings consistent with congenital Zika syndrome born to mothers with lab evidence of possible Zika virus infection during pregnancy MMWR October 20, 2017 Infants WITHOUT findings consistent with congenital Zika syndrome born to mothers with lab evidence of possible Zika virus infection during pregnancy Initial Evaluation •Standard evaluation (PE incl. growth parameters [wt/ht/HC], vision and developmental screen, newborn hearing screen) •Zika virus NAT and IgM testing •Head ultrasound by age 1 month •Comprehensive ophthalmologic exam by age 1 month •Automated ABR by age 1 month –if initial screen was otoacoustic emission methodology If initial evaluation is not normal, follow recommendations for infants with congenital Zika syndrome findings. MMWR October 20, 2017 https://www.cdc.gov/zika/pdfs/pediatric-evaluation-follow-up-tool.pdf Infants WITHOUT findings consistent with congenital Zika syndrome born to mothers with lab evidence of possible Zika virus infection during pregnancy Further Management •Standard evaluations –Routine pediatric care, immunizations, etc. –Be vigilant for signs associated with congenital Zika syndrome, refer if concerned. •Impaired visual acuity/function •Hearing problems •Developmental delay •Delay in head growth MMWR October 20, 2017 Infants WITHOUT findings consistent with congenital Zika syndrome born to mothers with lab evidence of possible Zika virus infection during pregnancy Further Management •If laboratory evidence of congenital Zika virus infection (positive Zika virus NAT or nonnegative Zika virus IgM with confirmatory neutralizing antibody testing) –Follow recommendations for infants with clinical findings of congenital Zika syndrome, even in absence of clinical abnormalities. •If no laboratory evidence of congenital Zika virus infection: –Congenital Zika virus infection is unlikely. –Continue routine care. Remain alert for new findings of congenital Zika virus infection. MMWR October 20, 2017 https://www.cdc.gov/zika/pdfs/pediatric-evaluation-follow-up-tool.pdf Infants WITHOUT findings consistent with congenital Zika syndrome born to mothers with possible Zika virus exposure during pregnancy but without lab evidence of possible Zika virus infection during pregnancy https://www.cdc.gov/zika/pdfs/pediatric-evaluation-follow-up-tool.pdf Infants WITHOUT findings consistent with congenital Zika syndrome born to mothers with possible Zika virus exposure during pregnancy but without lab evidence of possible Zika virus infection during pregnancy Initial and Further Management •Standard evaluation (PE incl. growth parameters [wt/ht/HC], vision and developmental screen, newborn hearing screen) •Zika testing not routinely recommended unless abnormal findings are identified. •If any findings consistent with congenital Zika syndrome are identified, refer to appropriate specialists and perform evaluation for infants with findings consistent with congenital Zika syndrome. MMWR October 20, 2017 Reporting Zika •Zika virus infections are nationally notifiable conditions. •Report lab confirmed and symptomatic cases of Zika to local health departments. –They should report to ArboNET. •US Zika Pregnancy Registry –https://www.cdc.gov/pregnancy/zika/research/re gistry.html General patient advice about Zika virus •Avoid traveling to Zika risk areas while pregnant. •There is no treatment or vaccine for Zika (yet). –Treat symptoms with supportive care. •Prevent mosquito bites while traveling to Zika risk areas. –Keep skin covered (long sleeves, etc.), sleep under mosquito bed or in air conditioned rooms. –Use mosquito repellent (DEET, etc.) https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/MosquitoBitePreventionLetterSize.pdf https://www.cdph.ca.gov/Programs/CID/DCDC/CDPH%20Document%20Library/InsectRepellentandPregnancyGuideFinal.pdf “Top 5 Things Everyone Needs to Know About Zika” [CDC] 1.Zika primarily spreads through infected mosquitoes. You can also get Zika through sex. 2.The best way to prevent Zika is to prevent mosquito bites. 3.Zika is linked to birth defects. 4.Pregnant women should not travel to areas with risk of Zika. 5.Returning traveler’s infected with Zika can spread the virus through mosquito bites and sex. https://www.cdc.gov/zika/pdfs/Top5.pdf Hope? For more information: Centers for Disease Control and Prevention (CDC) •https://www.cdc.gov/zika/ CA Dept of Public Health (CDPH) •https://www.cdph.ca.gov/Programs/CID/DCDC /Pages/Zika.aspx Additional Sources •World Health Organization: www.who.int/topics/zika/en/ •Petersen et al, “Zika Virus,” N. Engl J Med 374;16, April 21 2016 •Gubler et al, “History and Emergence of Zika Virus,” Journal of Infectious Diseases 2017:216(S10): S860-7. •Hills et al, “Epidemiology of Zika Virus Infection,” Journal of Infectious Diseases 2017:216(S10):S868-74. •Duffy et al, “Zika Virus Outbreak on Yap Island, Federated States of Micronesia,” N Engl J Med 360:24, June 11 2009. •Besnard et al, “Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014,” Euro Surveill, 2014;19(13). •Campos et al, “Zika Virus Outbreak, Bahia, Brazil,” Emerg Infect Dis Vol 21 No 10, October 2015. Additional Sources •Besnard et al, “Outcomes for 2 Children after Peripartum Acquisition, French Polynesia, 2013-2014,” Emerg Infect Dis Vol 23, No 8, August 2017. •Colt et al, “Transmission of Zika virus through breast milk and other breastfeeding-related body fluids: A systematic review,” PLOS Neglect Trop Dis, April 10, 2017. •Paz-Bailey et al, “Persistence of Zika Virus in Body Fluids – Preliminary Report,” N Engl J Med, Feb 14, 2017. •Nicastri et al, “Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveler returning from Haiti to Italy, February 2016,” Euro Surveill, v21(32), 2016 Aug 11. •Moore et al, “Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians,” JAMA Pediatrics, March 2017.